Meniran

DO not ever look down upon wild plants on the edge of the road, because it could be that plants have medicinal benefits.For example Meniran in Latin known as "Phyllanthus urinaria" which has reddish-green stems.This plant has compounds that can increase blood platelets, making it suitable to be an alternative drug for patients with Dengue Hemorrhagic Fever (DHF).Are five students of the Institute of Technology (ITS) Surabaya, which conducts research related to content Meniran it.Five young researchers ITS it is M. Burhan Rosyidi, Idya Rachmawati, Tyas Wulan Sari, Anga Premana and M Herman Eko.They have the idea of ​​making extracts Meniran into syrup that can be consumed for patients with DHF.The idea that the study was submitted to the Directorate of Higher Education (Higher Education) Ministry of National Education of Indonesia through the Student Creativity Program (PKM) a year ago and finally funded.To initiate research, and four colleagues gathered Idya Meniran. "We simply collect Meniran around campus course," he said.According to ITS Biology student, the idea that the utilization Meniran not easily be separated from the plant were found, including on campus."Meniran it grows wild and almost there on each side of the road, even on a dry field can also be found," he explained.Extraction-distillationFrom the study of literature, they know when the plant contains "flavonoids" that merit increases blood platelets."Flavonoids are substances that can enhance antibody useful in the formation of blood platelets, the same substance contained in guava," said another young researcher, Burhan.In the study, they tried to extract flavonoids Meniran to obtain, and then formulate and test it on test samples that have been infected by dengue virus.To extract the Organic Chemistry Laboratory of the five targeted students, in order to obtain pure flavonoid content.That process was not easy. "We sometimes have to mendestilasi Meniran until dissolved, then there are a few more processes such as chromatography column for final verification of flavonoids," he explained.Students from Gresik it tells the next job is to see the results of increased platelet counts in test animals (rats) that had been injected flavonoids."To see if the platelets are increased, then the bone marrow of rats were dissected. From the pieces of the spinal cord that can be known how many platelets with the addition Nacl first," he said.After that, the young team make comparisons and note if the number of platelets, animals were tested with extracts Meniran an increase greater than that do not."Research does not stop, because we still need a pure extract of flavonoids Meniran to be made into a syrup, so need to add some substance again," he said.The five young researchers from ITS was hoping Meniran later can be used as a drug for humans through the formulation of more appropriate dosage for human consumption, but consumption of vegetables directly to what is not.

Active CompoundsMedicinal Plants Meniran very rich in various chemical constituents, among others: phyllanthin, hypophyllanthin, niranthin, nirtetrali, nirurin, nirurinetin, norsecurinine, phyllanthenol, phyllnirurin, phylltetrin, quercitrin, quercetin, ricinoleic acid, routine, salicylic acid methyl ester, garlic acid, ascorbic acid, hinokinin, hydroxy niranthin, isolintetralin, and isoquercetin.
Other compounds contained in Meniran is beta-d-xylopyranoside and beta-sitosteroy. Another compound that was discovered is Seco-4-hidroksilintetralin, Seco-isoarisiresinol trimethyl ether, hidroksinirantin, dibenzilbutirolakton, nirfilin, and neolignan.
Roots and leaves are rich in flavonoids Meniran, among others phyllanthin, hypophyllanthin, qeurcetrin, isoquercetin, astragalin, and routine. Its seed oil contains several fatty acids such as ricinoleat acid, linoleic acid and linolenic acid.Scientific EvidenceThere are many benefits we can get from Medicinal Plants Meniran for our health. However, for pregnant women, the use is not recommended because Meniran Meniran is to abort the womb.
Patients with acute renal disorders are also prohibited from using Meniran as a drug. In addition, the use of Meniran in the long term may cause erectile dysfunction and kidney failure.Benefits Meniran as Medicine1. Antibacterial.Meniran leaf methanol extract had the highest antibacterial effect against Staphylococcus aureus, Bacillus subtilis, Escherichia colli, and Pseudomonas aeruginosa. This effect is due to the antibacterial compound on Meniran like phyllanthin, hypophyllanthin, niranthin, and nietetralin. Petroleum ether extract of the stems, leaves and roots Meniran also showed antifungal effects.2. Solvent of uric acid and kidney stones.The content of flavonoids and flavonoid glycosides are the compounds most frequently used in the treatment of gout and kidney stones. Therefore, Meniran flavonid-rich compounds, can be used to treat gout and kidney stones.
In the body, flavonoids bind with calcium from kidney stones then form a complex compound which easily soluble brown. Ions Na and K in Meniran would bind to uric acid salt forming compounds that easily dissolve in water so that has been crystallized uric acid in the blood and the kidneys will slowly dissolve and then be excreted in the urine.
Meniran also is a diuretic (helping discharge of urine). That way, Meniran used to treat gout and kidney stones or other illnesses caused by uric acid, such as rheumatic gout.3. Immunomodulator.Recent studies have revealed that Meniran immunomodulator activity. Immunomodulator role to make the system more active body of their duties, including strengthening the immune system / immune system. If the immune system increases, the body resistance against various bacteria and viruses also increases.
The immune system works with 3 ways. First, blocking the entry of bacteria and viruses into the body. Second, if bacteria and viruses made it into the body, the immune system will detect it and make the process of elimination before the bacteria and viruses multiply and cause disease. Third, if bacteria and viruses breed already, then the immune system will eliminate them.
The results showed that the extract Meniran can modulate the immune system through the proliferation (spread) and the activation of T lymphocytes and B, if our natural immune system resistance is insufficient. T and B lymphocytes to work according to the type of attack viruses and bacteria that occur. In addition, Meniran also serves to activate phagocytic cells such as monocytes and macrophages are responsible for providing a piece of pathogens (disease-causing biological agents) to T cells so that the pathogen can be identified and killed.
Because the character of immunomodulator, Meniran can be used to strengthen the immune system against bacteria, viruses, and microbes that cause disease in order to prevent various diseases caused by bacteria, viruses, or microbes.4. Anticancer.Ability Meniran as immunostimulator help stimulate the activity of natural killer cells (NK) cells and killer (K). If the toxicity of both cells increased, cells that have mutations and abnormal (cancer cells) will be destroyed by both.5. Antidiabetic.Phyllanthin and hypophyllanthin is a major component that allegedly played an active role in decreasing blood sugar levels. This is shown by the results of a study of mice that have been induced alloxan (a chemical that is given to trigger the condition of diabetes in experimental animals). Apparently, mice given Meniran extract decreased blood sugar levels. Meniran proven role as an antidiabetic.6. Hepatoprotector.The results showed that Meniran also serves as hepatoprotector. A group of mice injected with carbon tetrachloride (substance induced hepatotoxic). Apparently, to which water is boiled Meniran improved liver organ. Meniran antihepatotoksik containing compounds such as filantin, hipofilantin, triakontanal, and trikontanol.he
In addition, Phyllanthus compound in Meniran also known to work as a protector of the liver (hepatoprotector) by sabotaging the DNA polymerase (an enzyme needed for replication of hepatitis virus / replicate). In a study in India, 59% of patients suffering from hepatitis B infection showed levels of HBV infection after eating a little more Meniran for 1 month.7. Chronic hepatitis.Results of clinical trials in hospitals Soetomo prove efficacious Meniran overcome hepatitis B. Patients with chronic hepatitis Meniran given a capsule 3 times daily for a month. Meniran extract can modulate the immune system through the proliferation and activation of T and B lymphocytes Secretion of TNF-α and IFN-α also increased.
Effect finally, an indication of healing hepatitis. Meniran encourage repair mechanism of liver cells by increasing the number of enzymes that act as antioxidants.8. Antituberculosis.dr. Zulkifi Amin, an expert on tuberculosis immunology from the Faculty of Medicine, University of Indonesia, during the year 2000 Meniran conduct clinical trials of patients with tuberculosis. Clinical trials involved 60 patients aged 15-55 years. Patients were divided into 2 groups, each consisting of 30 members. Both groups were still given anti-tuberculosis drugs. The difference is, one group was given an additional well Meniran extract capsules 50 mg. Frequency 3 times a day each 1 capsule. During the 2 months of their situation continues to be monitored.
In the first week Meniran effects look very real. The number of acid-resistant bacteria (AFB, one indicator of TB) in patients who consume Meniran significantly reduced in the first week. The difference between the number of patients taking the BTA Meniran with a not very significant. Meniran helps increase levels of immunity to TB patients by increasing CD4 T lymphocytes and CD4/CD8 ratio of T lymphocytes9. Skin diseases.Meniran consumption is also useful as an adjunct therapy of skin diseases like leprosy and herpes zoster. Meniran extract works by increasing the cellular immune system. In other words, Meniran encourage more active T lymphocytes. Herpes zoster breed freely when the body's immune system is weakened.
While leprosy is a disease caused by the bacterium Mycobacterium leprae. The bacteria attack the skin and nervous system so that the edge of lepers ability to feel the stimulus of touch, heat, cold, pain will decrease. In the medical world, leprosy patients will be given antibiotics to keep the rate of disease progression.
The more severe the infection, the longer the antibiotic treatment is done so not infrequently appear in the form of drug side effects on skin rash, anemia, or liver damage. By eating Meniran that serves as an immunomodulator, immune system is stimulated and the healing process will occur more quickly.The number of properties that can be obtained from Meniran, making it as one of the leading medicinal plant a lot of interest. Savor Meniran the most popular in the community is its worth in dealing with uric acid. Therefore, almost every herbal products anti uric acid using Meniran as one of the raw materials of manufacture, such as tea made from herbs Sidaguri Sidaguri, combined with Meniran, Leaf god, and Sambiloto, which is believed to reduce uric acid levels, reducing swelling and pain.